e-Blood LYMPHOID NEOPLASIA Leukemia surfaceome analysis reveals new disease-associated features

نویسندگان

  • Paulina Mirkowska
  • Andreas Hofmann
  • Lukasz Sedek
  • Lucie Slamova
  • Ester Mejstrikova
  • Tomasz Szczepanski
  • Maike Schmitz
  • Gunnar Cario
  • Martin Stanulla
  • Martin Schrappe
  • Vincent H. J. van der Velden
  • Beat C. Bornhauser
  • Bernd Wollscheid
  • Jean-Pierre Bourquin
چکیده

Department of Oncology, University Children’s Hospital Zurich, Zurich, Switzerland; Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland; Life Science Zurich Graduate School, Zurich, Switzerland; Children’s Research Center, University Children’s Hospital Zurich, Zurich, Switzerland; Department of Pediatric Hematology and Oncology, Zabrze, Medical University of Silesia, Katowice, Poland; Department of Pediatric Hematology and Oncology, Charles University and University Hospital Motol, Prague, Czech Republic; Department of Pediatrics, University Hospital Schleswig Holstein, Kiel, Germany; and Department of Immunology, Erasmus MC, Rotterdam, The Netherlands

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Leukemia surfaceome analysis reveals new disease-associated features.

A better description of the leukemia cell surface proteome (surfaceome) is a prerequisite for the development of diagnostic and therapeutic tools. Insights into the complexity of the surfaceome have been limited by the lack of suitable methodologies. We combined a leukemia xenograft model with the discovery-driven chemoproteomic Cell Surface Capture technology to explore the B-cell precursor ac...

متن کامل

Relationship between ABO blood group and Acute Lymphoblastic Leukemia

Acute lymphoblastic leukemia (ALL) constitute a family of genetically heterogeneous lymphoid neoplasms derived from B- and T-lymphoid progenitors. ALL affects both children and adults. Diagnosis is based on morphologic, immunophenotypic, and genetic features that allow differentiation from normal progenitors and other hematopoietic and nonhematopoietic neoplasms. The aim of this study was to in...

متن کامل

Bioinformatics Analysis of the Human Surfaceome Reveals New Targets for a Variety of Tumor Types

It is estimated that 10 to 20% of all genes in the human genome encode cell surface proteins and due to their subcellular localization these proteins represent excellent targets for cancer diagnosis and therapeutics. Therefore, a precise characterization of the surfaceome set in different types of tumor is needed. Using TCGA data from 15 different tumor types and a new method to identify cancer...

متن کامل

Chronic lymphocytic leukemia, biology, new diagnosis and treatment: review article

Chronic lymphocytic leukemia (CLL) is a malignancy of B CD5+cells and is the most common type of leukemia in adults. The disease is more common in men over 50 years in western countries. CLL is associated with defective apoptosis in B cells. CLL was traditionally regarded as a disease that occurs before naïve B cells meet the antigen in the lymph nodes. Laboratory diagnosis requires white blood...

متن کامل

The Role of Exosomes in Myeloid and Lymphoid Blood Malignancies: A Systematic Review Article

Background and Aim: Blood malignancies, one of the most common cancers in the world, cause a large number of deaths each year. Many inherited and acquired factors are involved in the development of this disease. Exosomes are a very small model of cells that are secreted by most cells in the body under physiological and pathological conditions. On the other hand, they have found a special place ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2013